Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine.
نویسندگان
چکیده
The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45 degrees ), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.
منابع مشابه
Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus.
Downbeat nystagmus is a frequent ocular motor sign in patients with lesions of the vestibulocerebellum. The upward drift in downbeat nystagmus is a combination of a gaze-evoked drift, due to an impaired vertical neural integrator, and a velocity bias. Using a three-dimensional turntable, we analyzed the influence of gravity on these two mechanisms. Patients with cerebellar downbeat nystagmus (n...
متن کاملClinical/Scientific Notes Effect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus
The pathomechanism of downbeat nystagmus (DBN) remains controversial but each mechanism has to account for 1) its gazeevoked vertical centripetal component which increases on down and lateral gaze,1 and 2) the vertical bias component of the upward slow phase velocity (SPV) in gaze straight ahead. The vertical velocity bias of DBN has a gravity-dependent component which leads to maximal drift ve...
متن کاملEffect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus.
The pathomechanism of downbeat nystagmus (DBN) remains controversial but each mechanism has to account for 1) its gazeevoked vertical centripetal component which increases on down and lateral gaze,1 and 2) the vertical bias component of the upward slow phase velocity (SPV) in gaze straight ahead. The vertical velocity bias of DBN has a gravity-dependent component which leads to maximal drift ve...
متن کاملEffect of chlorzoxazone in patients with downbeat nystagmus: a pilot trial.
OBJECTIVE Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus with different symptoms such as unsteadiness of gait, postural instability, and blurred vision with reduced visual acuity (VA) and oscillopsia. However, different symptomatic therapeutic principles are required, such as 3,4-diaminopyridine and 4-aminopyridine, that effectively suppress DBN. Ch...
متن کاملThe effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus.
The GABAergic drug baclofen and the cholinergic drug physostigmine were administered to patients with upbeat and downbeat nystagmus. Baclofen (orally, 5 mg three times daily) reduced nystagmus slow phase velocity and distressing oscillopsia by 25-75% in four out of five patients (two upbeat nystagmus; two downbeat nystagmus). Physostigmine (1 mg single intravenous injection) increased nystagmus...
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ورودعنوان ژورنال:
- Neurology
دوره 67 5 شماره
صفحات -
تاریخ انتشار 2006